A stark violent streak over the weekend claimed the lives of four people while 40 others escaped with gun shots injuries.
Chicago police said the incident occurred during the seven hours from midnight Saturday to early Sunday morning.
Authorities said it happened in a city where violence has been decreasing this year.
“These were both random and targeted shootings on our streets,” said Fred Waller, Chief of the Patrol Division of the Chicago Police Department, in a press conference.
He said most of the shootings are connected to gang violence in the city of about 2.7 million people, the third-largest in the United States.
Police said gunmen targeted a block party, a gathering after a funeral, and other gatherings on a night where thousands of people gathered for a downtown concert.
Local media reported that the brunt of the violence happened in the city’s West Side, where 25 people were shot in separate attacks.